Thyroid, under-active

Overview

An underactive thyroid gland (hypothyroidism) is where your thyroid gland does not produce enough hormones.

Common signs of an underactive thyroid are tiredness, weight gain and feeling depressed.

An underactive thyroid can often be successfully treated by taking daily hormone tablets to replace the hormones your thyroid is not making.

There's no way of preventing an underactive thyroid. Most cases are caused either by the immune system attacking the thyroid gland and damaging it, or by damage to the thyroid that occurs during some treatments for an overactive thyroid or thyroid cancer.

When to see your GP

Symptoms of an underactive thyroid are often similar to those of other conditions, and they usually develop slowly, so you may not notice them for years.

You should see your GP and ask to be tested for an underactive thyroid if you have symptoms including:

tiredness
weight gain
depression
being sensitive to the cold
dry skin and hair
muscle aches

The only accurate way of finding out whether you have a thyroid problem is to have a thyroid function test, where a sample of blood is tested to measure your hormone levels.

Who's affected

Both men and women can have an underactive thyroid, although it's more common in women. Children can also develop an underactive thyroid and some babies are born with it.

All babies born in the UK are screened for congenital hypothyroidism using a blood spot test when the baby is about 5 days old.

Treating an underactive thyroid

Treatment for an underactive thyroid involves taking daily hormone replacement tablets, called levothyroxine, to raise your thyroxine levels.

You'll initially have regular blood tests until the correct dose of levothyroxine is reached. This can take a little while to get right.

Once you're taking the correct dose, you'll usually have a blood test once a year to monitor your hormone levels.

You'll usually need treatment for the rest of your life. However, with proper treatment, you should be able to lead a normal, healthy life.

If an underactive thyroid isn't treated, it can lead to complications, including heart disease, goitre, pregnancy problems and a life-threatening condition called myxoedema coma (although this is very rare).

The thyroid gland

The thyroid gland is a small butterfly-shaped gland in the neck, just in front of the windpipe (trachea).

One of its main functions is to produce hormones that help regulate the body's metabolism (the process that turns food into energy). These hormones are called triiodothyronine (T3) and thyroxine (T4).

Many of the body's functions slow down when the thyroid does not produce enough of these hormones.

Symptoms

Symptoms of an underactive thyroid

Many symptoms of an underactive thyroid (hypothyroidism) are the same as those of other conditions, so it can easily be confused for something else.

Symptoms usually develop slowly and you may not realise you have a medical problem for several years.

Common symptoms include:

tiredness
being sensitive to cold
weight gain
constipation
depression
slow movements and thoughts
muscle aches and weakness
muscle cramps
dry and scaly skin
brittle hair and nails
loss of libido (sex drive)
pain, numbness and a tingling sensation in the hand and fingers (carpal tunnel syndrome)
irregular periods or heavy periods

Elderly people with an underactive thyroid may develop memory problems and depression. Children may experience slower growth and development. Teenagers may start puberty earlier than normal.

If you have any of these symptoms, see your GP and ask to be tested for an underactive thyroid.

If an underactive thyroid is not treated

It's unlikely that you'd have many of the later symptoms of an underactive thyroid, because the condition is often identified before more serious symptoms appear.

Later symptoms of an underactive thyroid include:

a low-pitched and hoarse voice
a puffy-looking face
thinned or partly missing eyebrows
a slow heart rate
hearing loss
anaemia

Who can get it

An underactive thyroid (hypothyroidism) is when your thyroid gland does not produce enough of the hormone thyroxine (also called T4).

Most cases of an underactive thyroid are caused by the immune system attacking the thyroid gland and damaging it, or by damage that occurs as a result of treatments for thyroid cancer or an overactive thyroid.

Immune system

An underactive thyroid often occurs when the immune system, which usually fights infection, attacks the thyroid gland. This damages the thyroid, which means it's not able to make enough of the hormone thyroxine, leading to the symptoms of an underactive thyroid.

A condition called Hashimoto's disease is the most common type of autoimmune reaction that causes an underactive thyroid.

It's not clear what causes Hashimoto's disease, but it runs in families. It's also common in people with another immune system disorder, such as type 1 diabetes and vitiligo.

Previous thyroid treatment

An underactive thyroid can also occur as a side effect or complication of previous treatment to the thyroid gland, such as surgery or a treatment called radioactive iodine therapy.

These treatments are sometimes used for an overactive thyroid (where the thyroid gland produces too much hormone) or thyroid cancer.

Less common causes

Worldwide, a lack of dietary iodine is a common cause of an underactive thyroid, because the body needs iodine to make thyroxine. However, iodine deficiency is uncommon in the UK.

Babies are sometimes born with an underactive thyroid because the thyroid gland does not develop properly in the womb. This is called congenital hypothyroidism and is uncommon. It's usually picked up during routine screening soon after birth.

The Great Ormond Street Hospital for Children website has more information about congenital hypothyroidism and how it's treated.

A problem with the pituitary gland could lead to an underactive thyroid. The pituitary gland sits at the base of the brain and regulates the thyroid. Therefore, damage to the pituitary gland may lead to an underactive thyroid.

An underactive thyroid has also been linked to some viral infections or some medicines used to treat other conditions, such as:

lithium – a medicine sometimes used to treat certain mental health conditions, including depression and bipolar disorder
amiodarone – a medicine sometimes used to treat irregular heartbeats (arrhythmias)
interferons – a class of medicine sometimes used to treat certain types of cancer and hepatitis C

Speak to your GP or specialist if you're concerned that a medication you're taking may be affecting your thyroid hormone levels.

Diagnosis

It's very important that an underactive thyroid (hypothyroidism) is diagnosed as soon as possible.

Low levels of thyroid-producing hormones, such as triiodothyronine (T3) and thyroxine (T4), can change the way the body processes fat.

This can cause high cholesterol and atherosclerosis (clogging of the arteries), which can potentially lead to serious heart-related problems, such as angina and a heart attack.

Therefore, you should see your GP and ask for a blood test if you repeatedly have symptoms of an underactive thyroid.

Thyroid function test

A blood test measuring your hormone levels is the only accurate way to find out whether there's a problem.

The test, called a thyroid function test, looks at levels of thyroid-stimulating hormone (TSH) and thyroxine (T4) in the blood.

A high level of TSH and a low level of T4 in the blood could mean you have an underactive thyroid.

If your test results show raised TSH but normal T4, you may be at risk of developing an underactive thyroid in the future.

Your GP may recommend that you have a repeat blood test every so often to see whether you eventually develop an underactive thyroid.

Blood tests are also sometimes used for other measurements, such as checking the level of a hormone called triiodothyronine (T3). However, this is not routinely offered.

Less commonly, a thyroid antibody test may be recommended after a thyroid function test. This is to help diagnose or rule out autoimmune thyroid conditions, such as Hashimoto's thyroiditis. A thyroid antibody test is only likely to be recommended if your GP suspects you have an autoimmune thyroid condition.

Lab Tests Online UK has more information about the different types of thyroid function tests and thyroid antibody tests.

Referral

Your GP may refer you to an endocrinologist (a specialist in hormone disorders) if you:

are younger than 16
are pregnant or trying to get pregnant
have just given birth
have another health condition, such as heart disease, which may complicate your medicine
are taking a medicine known to cause a reduction in thyroid hormones, such as amiodarone or lithium

Treatment

An underactive thyroid (hypothyroidism) is usually treated by taking daily hormone replacement tablets called levothyroxine.

Levothyroxine replaces the thyroxine hormone, which your thyroid doesn't make enough of.

You'll initially have regular blood tests until the correct dose of levothyroxine is reached. This can take a little while to get right.

You may start on a low dose of levothyroxine, which may be increased gradually, depending on how your body responds. Some people start to feel better soon after beginning treatment, while others don't notice an improvement in their symptoms for several months.

Once you're taking the correct dose, you'll usually have a blood test once a year to monitor your hormone levels.

If blood tests suggest you may have an underactive thyroid, but you don't have any symptoms or they're very mild, you may not need any treatment. In these cases, your GP will usually monitor your hormone levels every few months and prescribe levothyroxine if you develop symptoms.

Taking levothyroxine

If you're prescribed levothyroxine, you should take 1 tablet at the same time every day. It's usually recommended that you take the tablets in the morning, although some people prefer to take them at night.

The effectiveness of the tablets can be altered by other medications, supplements or foods, so they should be swallowed with water on an empty stomach, and you should avoid eating for 30 minutes afterwards.

If you forget to take a dose, take it as soon as you remember, if this is within a few hours of your usual time. If you don't remember until later than this, skip the dose and take the next dose at the usual time, unless advised otherwise by your doctor.

An underactive thyroid is a lifelong condition, so you'll usually need to take levothyroxine for the rest of your life.

Side effects

Levothyroxine doesn't usually have any side effects, because the tablets simply replace a missing hormone.

Side effects usually only occur if you're taking too much levothyroxine. This can cause problems including sweating, chest pain, headaches, diarrhoea and vomiting.

Tell your doctor if you develop new symptoms while taking levothyroxine. You should also let them know if your symptoms get worse or don't improve.

Combination therapy

In the UK, combination therapy – using levothyroxine and triiodothyronine (T3) together – isn't routinely used because there's insufficient evidence to show it's better than using levothyroxine alone (monotherapy).

In most cases, suppressing thyroid-stimulating hormone (TSH) using high dose thyroid replacement therapy should be avoided because it carries a risk of causing adverse side effects, such as atrial fibrillation (an irregular and abnormally fast heart rate), strokes, osteoporosis and fracture.

However, this type of treatment may sometimes be recommended in cases where a person has a history of thyroid cancer and there's a significant risk of it reoccurring.

Underactive thyroid and pregnancy

It's important for the health of you and your baby that an underactive thyroid is treated properly before you become pregnant.

Tell your GP if you're pregnant or trying to become pregnant and you have hypothyroidism. They may refer you to a specialist for treatment and monitoring during your pregnancy.

Complications

Several complications can occur if you have an underactive thyroid that is not treated.

Heart problems

If you have an untreated underactive thyroid, your risk of developing cardiovascular disease is increased.

This is because having low levels of the hormone thyroxine can lead to increased levels of cholesterol in your blood. High cholesterol can cause fatty deposits to build up in your arteries, restricting the flow of blood.

Contact your doctor if you're being treated for an underactive thyroid and you develop chest pain, so that any problems can be detected and treated, if necessary.

Goitre

A goitre is an abnormal swelling of the thyroid gland that causes a lump to form in the throat. Goitres can develop in people with an underactive thyroid when the body tries to stimulate the thyroid to produce more thyroid hormones.

Pregnancy complications

If an underactive thyroid is not treated during pregnancy, there's a risk of problems occurring. These include:

pre-eclampsia – which can cause high blood pressure and fluid retention in the mother and growth problems in the baby
anaemia in the mother
an underactive thyroid in the baby
birth defects
bleeding after birth
problems with the baby's physical and mental development
premature birth or a low birthweight
stillbirth or miscarriage

These problems can usually be avoided with treatment under the guidance of a specialist in hormone disorders (an endocrinologist). Therefore, tell your GP if you have an underactive thyroid and you're pregnant or trying to get pregnant.

Myxoedema coma

In very rare cases, a severe underactive thyroid may lead to a life-threatening condition called myxoedema coma. This is where the thyroid hormone levels become very low, causing symptoms such as confusion, hypothermia and drowsiness.

Myxoedema coma requires emergency treatment in hospital. It's usually treated with thyroid hormone replacement medication given directly into a vein. In some cases, other treatments such as breathing support, antibiotics and steroid medication (corticosteroids) are also required.

The information on this page has been adapted by NHS Wales from original content supplied by

NHS website nhs.uk